|
KMID : 0387420000110020011
|
|
Korean Society of Oriental Neuropsychiatry
2000 Volume.11 No. 2 p.11 ~ p.21
|
|
|
Studies on the anti-inflammatory action of Taraxacum officinale extract in central nervous system
|
|
|
|
|
Abstract
|
|
|
|
Substance P(SP) can stimulate production of tumor necrosis factor-α(TNF-α) from astrocytes stimulated with lipopolysaccharide(LPS). The objective of the current study was to determine the effect of Taraxacum officinale(TO) on the production of TNF-α from primary cultures of rat astrocytes. TO(100 & 1000㎍/ml) significantly inhibited the TNF-α production by astrocytes stimulated with LPS and SP. Interleukin-1(IL-1) has been shown to elevate TNF-α production from LPS-stimulated astrocytes while having no effect on astrocytes in the absence of LPS. We therefore examined whether IL-1 mediated inhibition of TNF-α production from primary astrocytes by TO. Treatment of TO(100 and 1000㎍/ml) to astrocytes stimulated with both LPS and substance P decreased IL-1 production significantly. Moreover, the production of TNF-α by LPS and substance P in astrocytes was progressively inhibited with increasing amount of IL-1 neutralizing antibody. These results suggest that TO may inhibit TNF-α production by inhibiting IL-1 production and that TO has an antiinflammatory activity in the central nervous system.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|